Post Doctoral Associate-Aging Institute – Dr Gang Lis Lab

Post Doctoral Associate-Aging Institute – Dr Gang Lis Lab

Med-Aging Institute – Pennsylvania-Pittsburgh – 24001012

A Postdoctoral Associate position is available immediately in Dr. Gang Lis lab in the Aging Institute at the University of Pittsburgh, School of Medicine. The main research interest in Dr. Lis lab is to understand the molecular mechanisms underlying the contribution of disease-associated genetic variants to age-related diseases such as cancers, Alzheimers disease, and cardiovascular diseases. One of our current projects is to dissect the 58 kb core region on the CDDKN2A/B locus that is associated with atherosclerosis and its complications. The major focus is to reveal the mechanisms as well as the signaling pathways that activate cellular senescence and cell death. Of note, the accumulation of senescent cells with age is the most important contributor to aging and age-related diseases including multiple cardiovascular diseases. Our goal is to use human genetics GWAS as a guide to identify new drug targets and ultimately, we will apply our findings to develop allele-specific precision drugs for aging and age-related diseases. To accomplish this goal, we have developed a set of novel and highly efficient high throughput techniques Li et al., Nature Genetics 2018; Zhao et al., Nature Communications, 2020; Wu et al., Nucleic Acids Research, 2021 to study disease-associated risk genes such as p16^INK4A^ Jiang et al., Nature Aging, 2022, Wu et al., Aging Cell, 2022 manuscript accepted. The position could work on several projects that have very solid preliminary data, which will lead to high-impact publications in an efficient way. The candidate will have great opportunities to develop their unique professorship in both basic and translational studies by learning novel technologies as well as skills such as grant application and project management.

Interested candidates must be self-motivated and detail-oriented individuals with a commitment to research excellence. Candidates for postdoc positions require a PhD, MD, or MD/PhD degree with a strong background in molecular biology, genetics, and/or cell biology. Research experience in human and mouse genetics, cardiovascular diseases, Alzheimers disease, and functional genomics is preferred. Salary is based on NIH postdoc stipend levels, but is negotiable based on the candidates experience.

The University of Pittsburgh is committed to championing all aspects of diversity, equity, inclusion, and accessibility within our community. This commitment is a fundamental value of the University and is crucial in helping us advance our mission, which includes attracting and retaining diverse workforces. We will continue to create and maintain an environment that allows individuals to discover, belong, contribute, and grow, while honoring the experiences, perspectives, and unique identities of all.

The University of Pittsburgh is an Affirmative Action/Equal Opportunity Employer and values equality of opportunity, human dignity and diversity. EOE, including disability/vets.

Assignment Category: Full-time regular

Campus: Pittsburgh

Required Attachments: Curriculum Vitae

Assignment Category Full-time regular

PI251006487