Principal Scientist, Antibody Drug Conjugate (ADC) & Purification Development

We are LOTTE BIOLOGICS ! Delivering Therapies That Enable a Healthier World.

A new company, built on 80 years of tradition. We embody our core values of being Inspired by Science, Embracing Diversity, Fostering Talent, and Connecting Lives. Our mission is to be the most trusted partner in the industry, with high standards of quality and continuous innovation, to reliably deliver benefits for patients worldwide.

Position Summary

The Principal Scientist, Antibody Drug Conjugate & Purification Development position is responsible for to leading the process development and production of ADCs as part of a multi-disciplinary team to advance ADC development and provide on-floor GMP support of manufacturing. This role will also support development of the facility and laboratory design, build out, start-up, and technical process transfer of the ADC process from laboratory to manufacturing for ADCs and other large molecule bioconjugates for various therapeutic areas. In this critical role you will:

drive the CMC elements related to bioconjugation throughout the product life cycle using technical expertise in conjugation chemistry and downstream unit operations including tangential flow filtration, dead-end filtration, and protein chromatography

lead the design and execution of laboratory experiments in the development, optimization, and characterization of ADCs

leverage direct experience designing and implementing experiments to evaluate purification and bioconjugation processes for ADCs in order to lead development, execution, and technology transfer of purification and bioconjugation processes

develop, optimize, plan, and lead characterization of purification processes for antibodies and novel bioconjugation methodologies to improve antibody drug conjugates including High Throughput Screening methods for purification development

bring biologics from Phase I through commercial, including experience in late-stage activities such as CMC risk assessments, process characterization, and process validation, and provide technical experience for on-floor support for production of GMP antibody and ADC batches

Education & Experience

Degree in Biology, Chemistry, Biochemistry or Chemical Engineering, or equivalent area working in biologics downstream manufacturing or manufacturing technology: B.Sc/B.Eng degree with 9 years, M.Sc/M.Eng degree with 6 years, or Ph.D degree with 4 years of relevant industry experience

Experience with ADC chemistry, conjugation chemistry, reaction processes and purification process development and demonstrated hands-on experience in the generation of antibody drug conjugates

Experience working with Contract Development Manufacturing Organizations (CDMOs) is preferred

Qualifications

Hands-on experience and knowledge of protein purification and characterization using centrifugation, chromatography, normal-flow filtration, and tangential-flow filtration, as well as analytical techniques like Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid chromatography–mass spectrometry (LC-MS), Ion-Exchange (IEX), Reversed Phase (RP)-HPLC, routine DNA/RNA techniques, protein expression and purification, sodium dodecyl sulfate polyacrylamide gel electrophoresis, ultraviolet-visible spectrophotometry, and high-performance liquid chromatography

Work Environment

The position is based indoors and the individual will primarily be working with others, but also independently and alone at times in the laboratory

The office-based work will require sitting

The position is a team and project-based position that will require occasional shift work, weekends, evenings, and holidays

Dynamic, fast-paced, interactive, and entrepreneurial environment

Physical Demands

Laboratory-based position which requires appropriate levels of personal protective equipment (PPE). This role may require contact with biohazardous materials such as highly potent compounds, payload-linkers, and other hazardous chemicals including methotrexate, acids, and caustics. Powdered materials and high temperature liquids and solids may also be handled

Frequent repeated motions such as pipetting, lifting, bending, twisting, squatting, crouching, kneeling, climbing on step stools, and reaching may be required.

This role may also require unassisted lifting (not to exceed 50 lbs). Repetitive use of arms/hands/wrists and grasping may also be required

Supervisory Responsibilities

It’s important to note that during facility build and start-up phases, the ADC Principal Scientist will serve as an individual contributor but will transition to lead a team of scientists and engineers.

Travel

This position requires up to 10% of domestic and/or international travel.

Target Bonus:

16%

New York Pay Range

$91,000 — $142,000 USD

Work Location

East Syracuse, NY

We are an Equal Employment Opportunity (“EEO”) Employer.

We believe that women, people of color, veterans and LGBTQ communities must participate in the work we do, so we strongly encourage applications from people with these identities or who are members of underrepresented communities!  If this is the work that you want to do, in a culture of inclusion and excellence with the goal of making our world to be a healthier place, then please apply today!