Associate Director, Clinical Biomarker Lead (Immunologist)

Reference #: 404966
Site Name: USA – Pennsylvania – Upper Providence, UK – Hertfordshire – Stevenage
Posted Date: Sep 23 2024

Job title: Associate Director, Clinical Biomarker Lead  (Immunologist)

Location(s): USA – Pennsylvania – Upper Providence, UK – Hertfordshire – Stevenage

Precision Medicine (PMed) strives to leverage data to ensure we align the right
drug/dose/timing to the right patients to transform patient care and improve outcome. We utilize expertise in human disease, clinical pharmacology, biomarkers, imaging, and experimental medicine to define the optimal destination for cutting edge science to impact patient lives. It is under this umbrella that Clinical Biomarkers resides.

Are you passionate about science and wanting to make a difference to patients lives? At GSK, science is at the heart of everything we do. Join us to translate that great science into therapies as a Clinical Biomarker Lead (Associate Director)

In this role, you will have responsibility for development and effective implementation of biomarker and precision medicine strategy in support of clinical development of assets. Working as part of the early development / medicine development matrix teams (EDT/MDT), the Clinical Biomarker Lead will establish clear decision-making criteria to enable informed clinical decisions, identify patient segmentation strategies and integrate the strategy into the clinical development plans. You will employ cutting edge technologies and analysis methods to discover and clinically validate biomarkers. The implementation of the biomarker strategy as part of a well thought through clinical plan will ensure optimally informed decision making in drug development and identification of the right patient population for our medicines.

This role will provide YOU with the opportunity to progress YOUR career, and your responsibilities include:
Develop and deliver immunology and disease biomarker strategies including approaches to pharmacodynamic biomarkers, proof-of-mechanism and patient stratification biomarkers, for clinical phase programs in HBV to enable informed clinical decisions.
Develop and deliver precision medicine strategy to identify predictive biomarkers to enable clinical success.
Represent biomarker strategy at EDT/MDT, study teams and at internal governance reviews as well as serve as biomarker point of contact for clinical studies.
Ensure alignment of biomarker outputs with clinical team to meet study requirements.
Lead writing of reports to support study teams and regulatory submissions as well as contribute to publications.
Support the expansion of mechanism and disease understanding to generate insights that can be leveraged for indication expansion and scientific exchange.
Work closely with analysis teams to develop integrated analysis approaches to use high dimensional data to understand disease, patient subpopulations, mechanisms of drug response, and inform combination strategies.

Why you?
Basic Qualifications:
We are looking for professionals with these required skills to achieve our goals:

PhD in science, engineering, computational , or biology
Experience with immunology and at least 3 years post-graduate or industry experience
Experience in molecular biology including technologies, techniques and data analysis (e.g. flow cytometry, transcriptomics, proteomics, immuno-based assays)
Preferred Qualifications:

If you have the following characteristics, it would be a plus:

Experience and knowledge of infectious disease

Experience in omics and/or computational biology

Expertise in the discovery, validation and clinical implementation of biomarkers with a proven track record of success

Experience in conducting clinical trials and working as part of a clinical study team including working to GCP principles

Experience with diagnostic development

Ability to analyze and interpret molecular data sets

Ability to solve problems

Strong writing and presentation skills

Strong interpersonal skills and ability to thrive in a team setting

Ability to influence teams and key leaders with a proven track record of success
Why GSK?

Our values and expectations are at the heart of everything we do and form an important part of our culture.
These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

Agile and distributed decision-making – using evidence and applying judgement to balance pace, rigour and risk.
Managing individual and team performance.
Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
Implementing change initiatives and leading change.
Sustaining energy and well-being, building resilience in teams
Continuously looking for opportunities to learn, build skills and share learning both internally and externally
Developing people and building a talent pipeline
Translating strategy into action – a compelling narrative, motivating others, setting objectives and delegation
Building strong relationships and collaboration, managing trusted stakeholder relationships internally and externally
Budgeting and forecasting, commercial and financial acumen.

Please visit  GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?
Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, its also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

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