Scientist, Cell Biology – In Vivo Pharmacology

For Current Kite Pharma Employees and Contractors:

Please log onto your Internal Career Site (https://www.myworkday.com/gilead/d/inst/13102!CK5mGhIKBggDEMenAhIICgYI1A0QtgI~/cacheable-task/2997$2151.htmld#backheader=true) to apply for this job.

We’re here for one reason and one reason only – to cure cancer. Every moment is dedicated to developing treatments and every action moves us one step closer to our goal. We’ve made incredible scientific breakthroughs and our pioneering personalized CAR T-cell therapies have changed the paradigm. But were not finished yet.

Join Kite, as we make even bigger advances in cancer therapies, and help shape where our business and medical science goes next.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Kite and help create more tomorrows.

Job Description

As the largest, dedicated in-house cell therapy manufacturing network in the world, Kite has relentlessly focused on developing our industry-leading manufacturing capabilities to bring the hope of survival to more patients living with certain difficult-to-treat cancers.

The In Vivo Pharmacology team at Kite Pharma Foster City is seeking a Research Scientist to join an established group, to lead the development and characterization of in vivo murine models and associated ex vivo analyses for multiple cell therapy programs to address specific problematics related to engineered human chimeric antigen receptor T cells (CAR T cells).

Responsibilities:

Lead in vivo murine model development and characterization for multiple pipeline programs, for instance, specific tumor models and associated tumor microenvironment, immunodeficient mice humanized with specific human immune cell subsets or human umbilical cord blood-derived CD34 cells, to assess interactions of CAR T cells with host immune cells and CAR T-associated toxicities, in-house and/or via CRO companies

Design, plan, conduct, document, analyze and interpret preclinical in vivo studies in support of multiple programs, based on plan, project timelines and goals

Provide mechanistic data from preclinical mouse studies and/or in vitro cell-based assays, utilizing flow cytometry, molecular biology, or other analytical techniques through the characterization of immune parameters such as cell expansion, distribution and phenotype, cytokine profile, from ex vivo samples (blood, plasma, serum, tumor, tissues)

Mentor and guide junior colleagues

Work collaboratively and effectively in a cross-functional team environment

Present and participate in project team meetings and cross-departmental team meetings

Share core values suchas passion, courage, teamwork, integrity and trust

Basic Qualifications:

Advanced scientific degree (i.e. MD, PharmD, PhD) OR

Master’s Degree and 6 years of scientific experience OR

Bachelor’s Degree and 8 years of scientific experience OR

High School Diploma/GED and 12 years of scientific experience

Preferred Qualifications:

Education and thorough background in immunology / cancer immunotherapy and multi-parameter flow cytometry with experience in phenotypic analysis of multiple human immune cell populations and markers of activation/exhaustion

Deep understanding of mechanisms of xenogeneic GvHD, T-cell alloreactivity, immunity of murine models such as NSG mice, humanized mice reconstituted with human immune cells

Direct experience working with engineered human T cells and/or other immune cell types

Experience in T-cell functional characterization assays including in vitro cytotoxicity, proliferation, cytokine/chemokine measurements, cell signaling, activation, differentiation, and exhaustion

Proficient in multi-parameter flow and/or spectral cytometry (antibody titration, panel design, sample acquisition, data processing) and data analysis (FACSDiva, FlowJo, GraphPad Prism, Excel)

Proficient in cell culture aseptic technique

Experience with mouse tumor models, mouse handling and techniques including dosing (IV, subcutaneous, PO and IP), tumor inoculation and measurements, in-life and terminal blood collection, necropsy, tissue collection and processing

Experience in molecular and cellular biology techniques, including but not limited to: phospho-flow, ELISA, Luminex/MSD-based assays, ddPCR, western blot

Demonstrated independence in experimental design, data analysis, interpretation, and presentation, critical thinking and problem-solving skills

Thorough organizational andtime-management skills, high degree of accuracy and attention to detail, thorough record keeping skills (documentation and electronic lab notebook), excellent collaborative, interpersonal, verbal and written communication skills

Self-motivated, thorough senseof responsibility, drive to learn and make a meaningful impact

Comfortable in a flexible and fast-paced company environment and able to adjust workload based upon changing priorities

Understands and implements study protocols in accordance with regulatory requirements for compliance with IACUC/AAALAC guidelines

The salary range for this position is: $143,225.00 – $185,350.00. Kite considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans.

For additional benefits information, visit:

https://www.gilead.com/careers/compensation-benefits-and-wellbeing

Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

Kite is a biopharmaceutical company engaged in the development of innovative cancer immunotherapies with a goal of providing rapid, long-term durable response and eliminating the burden of chronic care. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune systems ability to recognize and kill tumors. Kite is based in Santa Monica, CA. For more information on Kite, please visit www.kitepharma.com . Sign up to follow @KitePharma on Twitter at www.twitter.com/kitepharma .

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For Current Kite Pharma Employees and Contractors:

Please log onto your Internal Career Site (https://www.myworkday.com/gilead/d/inst/13102!CK5mGhIKBggDEMenAhIICgYI1A0QtgI~/cacheable-task/2997$2151.htmld#backheader=true) to apply for this job.

Change The World With Us

Everyone at Kite is grounded by one common goal – curing cancer. Every day, we aim to establish a direct line between that purpose and our day-to-day work.

We are creating Kite together, with the recognition that the best teams are built by the best people. We maintain an attitude of curiosity, and creativity with each challenge as we develop a new market for cancer therapies. We appreciate and respect one another, and most importantly, we don’t take success for granted.

While we’ve come a long way to make what others viewed as impossible, possible, we know one thing is certain. Today is just the beginning.